The Search for Genetic Modifiers
The age of onset varies widely in Huntington's Disease, from infancy to old age. Statistical analysis of large samples of patients shows that the single most important factor influencing age of onset is the CAG count, explaining about two-thirds of the variance. The higher the count, the earlier the average age of onset. Although this relationship is very clear on the aggregate level, there are significant variations among individuals and it is possible for two people with the same count to have onsets a decade or more apart.
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