A comparison of Huntington disease and Huntington diseaselike 2

A comparison of Huntington disease and Huntington diseaselike 2 neuropathologyDobrila D. Rudnicki et al., J. Neuropathol. Exp. Neurol. (2008), 67:366-374In recent years, a number of neurological disorders have been identified where patients present with a clinical picture similar to that seen in Huntington's disease (HD). To date, four "Huntington' s disease-like" (HDL) syndromes have been recognised. This study compared post mortem brains from Huntington's disease and Huntington's disease-like 2 patients. Neuropathological features of both diseases were very similar, suggesting that the pathogenic mechanisms underlying the two diseases might overlap.