Weight loss in Huntington disease increases with higher CAG repeat number

Weight loss in Huntington disease increases with higher CAG repeat number N. Ahmad Aziz et al., Neurology (2008), 71:1506-1513This study shows that the rate of weight loss in Huntington's disease is directly proportional to the length of the CAG repeat in the HD gene, and is likely to result from a hypermetabolic state. Participants (517 early stage HD patients) were recruited from the European Huntington's Disease Initiative, a phase III interventional clinical trial.Detection of Huntington's disease decades before diagnosis.