Predict-HD studyJane S. Paulsen et al., J. Neurol. Neurosurg. Psychiatry

Predict-HD studyJane S. Paulsen et al., J. Neurol. Neurosurg. Psychiatry (2008), 79:874-880This study shows that small changes in clinical and neuroimaging parameters are detectable long before the predicted onset of Huntington's disease, and proposes a model establishing the relationship between different clinical outcomes and estimated age at diagnosis.The relationships between estimated years to diagnosis and motor scores, striatal volume, odour retention and cognitive measures were strikingly consistent. Understanding the initial steps in HD pathogenesis could facilitate early clinical diagnosis, and improve trials of candidate drugs aimed at delaying disease onset or slowing the rate of disease progression.